Articles in Press
Volume 2 Issue 1
A Comprehensive Review in Development of Thiazolo[5,4-d]pyrimidines Based Molecules in Medicinal Chemistry
Bhimanna Kuppast, Mohamed Teleb, Hesham Fahmy*
Thiazolo[5,4-d]pyrimidines are important fused heterocyclic ring-systems which can be considered as purine bioisosteres by virtue of replacement of the nitrogen at position 9 of the purine ring with a sulfur atom. Because of this structural resemblance to purine, there is also structural similarity with adenine and guanine and their related derivatives such as adenosine, guanosine, cAMP, cGMP and other similarly-related biomolecules.