Volume 2 Issue 1
A Comprehensive Review in Development of Thiazolo[5,4-d]pyrimidines Based Molecules in Medicinal Chemistry
Bhimanna Kuppast, Mohamed Teleb, Hesham Fahmy*
Thiazolo[5,4-d]pyrimidines are important fused heterocyclic ring-systems which can be considered as purine bioisosteres by virtue of replacement of the nitrogen at position 9 of the purine ring with a sulfur atom. Because of this structural resemblance to purine, there is also structural similarity with adenine and guanine and their related derivatives such as adenosine, guanosine, cAMP, cGMP and other similarly-related biomolecules.
The Effect of Thiol Containing Compounds on the Kinetics of Sickle Hemoglobin Polymerization
Ahmed S. Mehanna*, Moataz A. Hendawy
The current research reports the anti-polymerization activities of thirteen thiol containing compounds. The evaluation was conducted using our newly reported high throughput kinetic assay designed to study sickle hemoglobin polymerization kinetics. The evaluated compounds ranged from thiol containing amino acids and chemicals to marketed drugs containing the thiol functionality.